Globally, climate change continues to disrupt food systems. Determinants such as gradually rising temperatures and extreme weather patterns have a significant impact on these systems resulting in inconsistencies that ultimately impair their sustainability. This study focused on investigating climate-induced discrepancies in food system synergy and their impact on the sustainability of youth agripreneurs. The study was conducted in the Musina municipality of the Limpopo province. Simple random sampling was used to select the study participants, while structured questionnaires were administered during in-person interviews. The multinomial logistic regression model was used to investigate the influence of climate-induced discrepancies on the sustainability of agribusiness enterprises owned by young farmers. The study’s findings revealed that climate-induced discrepancies had a severe impact on the collapse, survival, and sustainability of agribusiness enterprises. Subsequently, these discrepancies had both progressive and regressive influences on the sustainability of agribusiness enterprises at various stages of their life cycle. At a policy level, the study recommends joint collaborative investment efforts in localized input manufacturing facilities, as this will help mitigate fluctuations in input prices and sustain their availability. . Future studies could focus on integrating the economic viability of a commodity-tailored resilience approach, thereby providing insights into the coping mechanisms that are ideal and cost-effective for specific regions and agricultural enterprises.

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